Phosphorus pentachloride → N-(2-chlorophenyl)-5-(methylsulfonyl)picolinimidoyl chloride

HRID 1478121Notes

Reaction equation

HRID 1478121 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][N:11]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:22]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]([Cl:22])[C:10]1[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][N:11]=1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 67958704N-(2-chlorophenyl)-5-(methylsulfonyl)picolinamide

Product 1

HCID 86709639N-(2-chlorophenyl)-5-(methylsulfonyl)picolinimidoyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

N-(2-chlorophenyl)-5-(methylsulfonyl)picolinamide 5 (1.26 g, 0.0040 mol) in anhydrous benzene (20 mL) was added to PCl5 (1.26 g, 0.0060 mol) and the mixture was heated to reflux overnight. The solvent was removed and the residue was further dried under high vacuum. Crude N-(2-chlorophenyl)-5-(methylsulfonyl)picolinimidoyl chloride 6 was obtained as a yellow solid (1.60 g). The compound 6 was dissolved into anhydrous THF (30 mL) and the reaction was cooled down to 0° C. and hydrazine hydrate (9.0 mL) was added. The reaction was kept at 0° C. for 10 min and warmed to ambient temperature in 0.5 h. The solvent was removed and the residue was purified by column chromatography (eluting with hexane and ethyl acetate 1:1) to give N′-(2-chlorophenyl)-5-(methylsulfonyl) picolinimidohydrazide 7 as a yellow solid. Yield: 1.22 g, 92.0%.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux overnight
  3. customThe solvent was removed
  4. customthe residue was further dried under high vacuum

Sources & evidence

ORD record
ord-fa2cc3de9ca543f58f926a5df439cd5d
Source dataset
uspto-grants-2016_08
Patent number
US09403812B2

Reaction notes

Loading…