Potassium Phosphate, Tribasic → Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate

Participants

Reaction Steps

A mixture of EXAMPLE 1G (8.5 g), methyl 2,4-difluorobenzoate (7.05 g), and K3PO4 (9.32 g) in diglyme (40 mL) at 115° C. was stirred for 24 hours. The reaction was cooled, diluted with ether (600 mL), and washed twice with water, and brine, and concentrated. The residue was purified by flash chomatography, eluting with 2-50% ethyl acetate in hexanes to provide the title compound.

Provenance & Evidence