Bromotrimethylsilane → Ethyl 5-(4-bromo-5-methyltetrahydro-2H-pyran-2-yl)-4-methylisoxazole-3-carboxylate

To an ice-cooled mixture of 2-methylbut-3-en-1-ol (Aldrich) (0.171 mL, 1.638 mmol), indium (III) bromide (28.3 mg, 0.082 mmol) and dry DCM (10 mL) under nitrogen, was added bromotrimethylsilane (0.213 mL, 1.638 mmol). The reaction mixture was stirred with ice cooling for 30 mins. A solution of ice cold ethyl 5-formyl-4-methylisoxazole-3-carboxylate (Intermediate C) (300 mg, 1.638 mmol) in dry DCM (2 mL) was added to the reaction mixture over a 5 minute period. The reaction mixture was stirred with ice cooling and warmed to room temperature over the weekend. The resulting mixture was treated with saturated aqueous NaHCO3 (10 ml) with stirring at 0° C. The resulting mixture was passed through a phase separating cartridge and the eluent solvent was removed under reduced pressure. The crude material was dissolved in DMSO and purified using UV-directed automated reverse phase chromatography over a 9.5 minute gradient of 50-98% MeCN in water (0.1% formic acid). The product fractions were added to EtOAc (50 mL) and washed with saturated aqueous NaHCO3 (50 ml). The organics were dried over MgSO4, filtered and the solvent removed under reduced pressure to afford the title compound;

1. stirringThe reaction mixture was stirred with ice cooling
2. stirringwith stirring at 0° C
3. customseparating cartridge
4. customthe eluent solvent was removed under reduced pressure
5. dissolutionThe crude material was dissolved in DMSO
6. custompurified
7. customover a 9.5 minute
8. additionThe product fractions were added to EtOAc (50 mL)
9. washwashed with saturated aqueous NaHCO3 (50 ml)
10. dry with materialThe organics were dried over MgSO4
11. filtrationfiltered
12. customthe solvent removed under reduced pressure

ORD record

ord-01a193e2388e475596447fcb5a68f19a

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09403810B2