反应详情

A mixture of cyclobutanone (16.96 ml, 227 mmol) and tert-butyl hydrazinecarboxylate (30 g, 227 mmol) in isohexane (378 mL), under nitrogen was stirred at reflux for 1 hour. The reaction mixture was cooled to room temperature and stirred for 1 hour. The resulting suspension was filtered, rinsing the solid with iso-hexane (×2). The solid was dried under vacuum at 30° C. to afford the title compound;

1. temperatureat reflux for 1 hour
2. stirringstirred for 1 hour
3. filtrationThe resulting suspension was filtered
4. washrinsing the solid with iso-hexane (×2)
5. customThe solid was dried under vacuum at 30° C.