tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylate → HCID 86697430, compound

HRID 1478259Notes

Reaction equation

HRID 1478259 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][C:8](Cl)=[N:7][C:6]=12.[NH2:12][CH2:13][C@@H:14]1[CH2:18][CH2:17][CH2:16][N:15]1[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][C:8]([NH:12][CH2:13][C@@H:14]3[CH2:18][CH2:17][CH2:16][N:15]3[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[N:7][C:6]=12

Participants

3

Reactant 2

HCID 1512533tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylateHCID 454805073-Bromo-5-chloropyrazolo(1,5-a)pyrimidine

Product 1

HCID 86697430HCID 86697430, compoundYield 74%

Procedure

The reaction of 3-bromo-5-chloropyrazolo[1,5-a]pyrimidine and (S)-tert-butyl 2-(aminomethyl)pyrrol-idine-1-carboxylate under the amine displacement conditions described in example 5.6.5 afforded 74% product.

Sources & evidence

ORD record
ord-f6d96732dac14925b1c52cdb5b0aa995
Source dataset
uspto-grants-2016_08
Patent number
US09403832B2

Reaction notes

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