HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1478274Generated: November 2, 2026
Diisopropylethylamine → HCID 86697441, compound
https://huagongshe.com/reaction/1478274
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 3-Bromo-5-chloropyrazolo(1,5-a)pyrimidine | HCID 45480507 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86697441 | HCID 86697441 | 96.4% |
Reaction Steps
3-bromo-5-chloropyrazolo[1,5-a]pyrimidine (10 g, 43 mmol) taken up in isopropanol. T-butylpiperazine carboxylate (9.61 g, 51.6 mmol), diisopropylethylamine (22.4 mL, 129 mmol) added and stirred at 65° C. overnight. Reaction was cooled to room temperature, diluted with water and solid product filtered off. The solid was washed with water, dried to obtain 15.84 g crude product for further reaction, as is. LRMS (ESI) m/z 382/384 [(M+H)]+, calc'd for C15H20BrN5O2: 382.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09403832B2 |
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| Source dataset | uspto-grants-2016_08 |
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| ORD ID | ord-be8e51cab00b4b4d98c492e09f2c7f68 |
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| Source note | uspto-grants-2016_08 |
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