1-Methoxy-2-propanol → 1-Methoxypropan-2-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

HRID 1478288Notes

Reaction equation

HRID 1478288 reaction equation
COCC(O)C.[Br:7][C:8]1[CH:9]=[N:10][N:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][N:20]([C:23]([O:25][C@@H:26]4[CH2:30][CH2:29][O:28][CH2:27]4)=[O:24])[CH2:19][CH2:18]3)=[N:13][C:12]=12>>[Br:7][C:8]1[CH:9]=[N:10][N:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:18][CH2:19][N:20]([C:23]([O:25][CH:26]([CH3:30])[CH2:27][O:28][CH3:29])=[O:24])[CH2:21][CH2:22]3)=[N:13][C:12]=12

Participants

3

Reactant 2

HCID 79001-Methoxy-2-propanolHCID 86697452(R)-tetrahydrofuran-3-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Product 1

HCID 866974531-Methoxypropan-2-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Procedure

This was made by using 1-methoxypropan-2-ol and following the Part B in the procedure described above for making (R)-tetrahydrofuran-3-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate.

Sources & evidence

ORD record
ord-7e0bd3461a534e24aaeb299fa7a5d62e
Source dataset
uspto-grants-2016_08
Patent number
US09403832B2

Reaction notes

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