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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1478293Generated: October 30, 2026

(4-Chloro-3-methyl-2-pyridyl)-cyclopropyl-methanol → (4-Chloro-3-methyl-2-pyridyl)cyclopropylketone

https://huagongshe.com/reaction/1478293

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Chloro-3-methyl-2-pyridyl)-cyclopropyl-methanolHCID 12071707—
CatalystManganese dioxideHCID 14801—
SolventDichloromethaneHCID 6344—
Product(4-Chloro-3-methyl-2-pyridyl)cyclopropylketoneHCID 6698031798.2%

Reaction Steps

A solution of (3-methyl-4-chloro-pyridin-2-yl)-cyclopropyl-methanol (7.01 g, 35.5 mmol) in DCM (80 mL) was treated with MnO2 (30.8 g, 355 mmol) at room temperature overnight. The reaction mixture was filtered through a pad of Celite and the filtrate was concentrated to dryness, affording the title compound (6.82 g, 98%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09403818B2
Source datasetuspto-grants-2016_08
ORD IDord-3b7ef9d82e004f1dad9edc5952387463
Source noteuspto-grants-2016_08