HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-[4-(Aminomethyl)-3-fluoro-phenyl]-1-cyclopropyl-9-methyl-4-oxoquinolizine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 8-(4-((tert-butoxycarbonylamino)methyl)-3-fluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid | HCID 86696585 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-[4-(Aminomethyl)-3-fluoro-phenyl]-1-cyclopropyl-9-methyl-4-oxoquinolizine-3-carboxylic acid | HCID 56960956 | — |
Reaction Steps
A solution of 4M hydrochloric acid in dioxane (1 mL, 4 mmol) was added to a solution of 8-(4-((tert-butoxycarbonylamino)methyl)-3-fluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid (24 mg, 0.051 mmol) in ACN (4 mL). The mixture was stirred for 4 h and a suspension was formed. The product compound 4 was collected by filtration (17.7 mg, 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403818B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-604de3edfa864502a15b78aa83fd5629 |
| Source note | uspto-grants-2016_08 |