4-Cyanophenylboronic acid → HCID 86696575, compound

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Reaction Steps

Ethyl 8-(4-cyano-phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A from ethyl 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (151 mg, 0.47 mmol) and 4-cyano-phenyl-boronic acid (82 mg, 0.56 mmol). Purification by flash silica column chromatography (DCM:MeOH, 1:0 to 9:1) afforded the title compound as a yellow solid (189 mg, 100%).

Provenance & Evidence