Methanol → 2-(3,3-Difluorocyclopentyl)-2-hydroxy-2-phenylacetic acid

HRID 147836Notes

Reaction equation

HRID 147836 reaction equation
[C:1]([CH:2]1[O:6][C:7]([c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)([CH:17]2[CH2:18][C:19]([F:22])([F:23])[CH2:20][CH2:21]2)[C:8](=[O:10])[O:9]1)([CH3:3])([CH3:4])[CH3:5].[CH3:26][OH:27].[Na+:25].[OH-:24]>>[OH:6][C:7]([C:8](=[O:9])[OH:10])([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:17]1[CH2:18][C:19]([F:22])([F:23])[CH2:20][CH2:21]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 99491572-Tert-butyl-5-(3,3-difluorocyclopentyl)-5-phenyl-1,3-dioxolan-4-one

Product 1

HCID 99547772-(3,3-Difluorocyclopentyl)-2-hydroxy-2-phenylacetic acid

Sources & evidence

ORD record
ord-5ba13d6019fc48fc848193ca6e18df76
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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