HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-1H-indazole-5-boronic acid → HCID 86696776, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-1H-indazole-5-boronic acid | HCID 22558910 | — |
| Reactant | Methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-quinolizine-3-carboxylate | HCID 86696543 | — |
| Product | HCID 86696776 | HCID 86696776 | 98.5% |
Reaction Steps
Methyl 8-(1-methyl-1H-indazol-5-yl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A′ from methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (100 mg, 0.34 mmol) and (1-methyl-1H-indazol-5-yl)boronic acid (176.0 mg, 0.41 mmol). Purification by flash silica column chromatography (DCM:MeOH) (1:0 to 9:1) afforded the title compound as a yellow solid (129.8 mg, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403818B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-17776e6192e44362bc6e7f0bc896628b |
| Source note | uspto-grants-2016_08 |