Propionyl chloride → HCID 86709305, compound

HRID 1478390Notes

Reaction equation

HRID 1478390 reaction equation
[N:1]1([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][C:19]4[CH:24]=[CH:23][C:22]([C:25]5[NH:29][N:28]=[CH:27][CH:26]=5)=[CH:21][CH:20]=4)[CH:14]=3)[N:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:30](Cl)(=[O:33])[CH2:31][CH3:32]>>[N:28]1[NH:29][C:25]([C:22]2[CH:21]=[CH:20][C:19]([O:18][C:13]3[CH:14]=[C:15]4[C:10](=[CH:11][CH:12]=3)[N:9]=[C:8]([CH2:7][N:1]3[CH2:6][CH2:5][N:4]([C:30](=[O:33])[CH2:31][CH3:32])[CH2:3][CH2:2]3)[CH:17]=[CH:16]4)=[CH:24][CH:23]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 86709306HCID 86709306, compound

Product 1

HCID 86709305HCID 86709305, compound

Procedure

The title product (12) is prepared from intermediate F (40.0 mg, 0.087 mmol) and propionyl chloride (9.5 μL, 0.11 mmol) according to the procedure described for the synthesis of Example 10.

Workup

  1. customdescribed for the synthesis of Example 10

Sources & evidence

ORD record
ord-64ef79c12acc4cf3a71daccf459d7fe1
Source dataset
uspto-grants-2016_08
Patent number
US09403830B2

Reaction notes

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