HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86709308, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | L-Lactic Acid | HCID 107689 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 86709306 | HCID 86709306 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86709308 | HCID 86709308 | — |
Reaction Steps
A stirred suspension of intermediate F (35.0 mg, 0.076 mmol) in DCM (2.00 mL) is treated with L-(+)-lactic acid (17.2 mg, 0.191 mmol), triethylamine (53 mL, 0.382 mmol) and TBTU (30.7 mg, 0.095 mmol). After 72 h, the mixture is concentrated and purified using silica gel flash chromatography (0-10% MeOH in DCM) to afford the title compound (13).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403830B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-9c16b221a6ab44aeb9d775a929c2e178 |
| Source note | uspto-grants-2016_08 |