1-Hydroxy-1-cyclopropanecarboxylic acid → HCID 86709307, compound

HRID 1478392Notes

Reaction equation

HRID 1478392 reaction equation
[N:1]1([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][C:19]4[CH:24]=[CH:23][C:22]([C:25]5[NH:29][N:28]=[CH:27][CH:26]=5)=[CH:21][CH:20]=4)[CH:14]=3)[N:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[OH:30][C:31]1([C:34](O)=[O:35])[CH2:33][CH2:32]1.O[C@@H](C)C(N1CCN(CC2C=CC3C(=CC=C(OC4C=CC(C5NN=CC=5)=CC=4)C=3)N=2)CC1)=O>>[OH:30][C:31]1([C:34]([N:4]2[CH2:5][CH2:6][N:1]([CH2:7][C:8]3[CH:17]=[CH:16][C:15]4[C:10](=[CH:11][CH:12]=[C:13]([O:18][C:19]5[CH:20]=[CH:21][C:22]([C:25]6[NH:29][N:28]=[CH:27][CH:26]=6)=[CH:23][CH:24]=5)[CH:14]=4)[N:9]=3)[CH2:2][CH2:3]2)=[O:35])[CH2:33][CH2:32]1

Participants

4

Reactant 3

HCID 27331601-Hydroxy-1-cyclopropanecarboxylic acidHCID 86709306HCID 86709306, compoundHCID 86709308HCID 86709308, compound

Product 1

HCID 86709307HCID 86709307, compound

Procedure

The title compound 15 is synthesized from intermediate F (35 mg, 0.076 mmol), and 1-hydroxy-1-cyclopropanecarboxylic acid (19 mg, 0.19 mmol) according to the procedure described for the synthesis of compound 13.

Sources & evidence

ORD record
ord-8d5d32a164294d3ab87271e0b4a664c5
Source dataset
uspto-grants-2016_08
Patent number
US09403830B2

Reaction notes

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