Octahydropyrrolo[1,2-a]piperazin-6-one → HCID 86709312, compound

HRID 1478394Notes

Reaction equation

HRID 1478394 reaction equation
C[Si](C)(C)CCOC[N:7]1[C:11]([C:12]2[CH:13]=[CH:14][C:15]([O:18][C:19]3[CH:20]=[C:21]4[C:26](=[CH:27][CH:28]=3)[N:25]=[C:24]([CH:29]=O)[CH:23]=[CH:22]4)=[N:16][CH:17]=2)=[CH:10][CH:9]=[N:8]1.[CH2:33]1[NH:38][CH2:37][CH2:36][N:35]2[C:39](=[O:42])[CH2:40][CH2:41][CH:34]12.N1NC(C2C=CC(OC3C=C4C(=CC=3)N=C(CN3CCC(N5CCOC5=O)CC3)C=C4)=NC=2)=CC=1>>[N:8]1[NH:7][C:11]([C:12]2[CH:13]=[CH:14][C:15]([O:18][C:19]3[CH:20]=[C:21]4[C:26](=[CH:27][CH:28]=3)[N:25]=[C:24]([CH2:29][N:38]3[CH2:37][CH2:36][N:35]5[C:39](=[O:42])[CH2:40][CH2:41][CH:34]5[CH2:33]3)[CH:23]=[CH:22]4)=[N:16][CH:17]=2)=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 10820612Octahydropyrrolo[1,2-a]piperazin-6-oneHCID 86709310HCID 86709310, compoundHCID 86709311HCID 86709311, compound

Product 1

HCID 86709312HCID 86709312, compound

Procedure

The title compound 18 is synthesized from intermediate D (0.100 g, 0.224 mmol) and hexahydro-pyrrolo[1,2-a]pyrazin-6-one (78.5 mg, 0.560 mmol) according to the procedure described for the synthesis of compound 11.

Sources & evidence

ORD record
ord-f11ebde1552443bd87cf6053d06df066
Source dataset
uspto-grants-2016_08
Patent number
US09403830B2

Reaction notes

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