Acetyl chloride, 2-(2-chlorophenyl)- → Methyl 5-bromo-2-(2-(2-chlorophenyl)acetamido)benzoate

HRID 1478515Notes

Reaction equation

HRID 1478515 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](Cl)=[O:10].[Br:12][C:13]1[CH:14]=[CH:15][C:16]([NH:23]C(=O)CC2C=CC=C(C(F)(F)F)C=2)=[C:17]([CH:22]=1)[C:18]([O:20][CH3:21])=[O:19]>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([NH:23][C:9](=[O:10])[CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])=[C:17]([CH:22]=1)[C:18]([O:20][CH3:21])=[O:19]

Participants

3

Reactant 2

HCID 182669Acetyl chloride, 2-(2-chlorophenyl)-HCID 118005521Methyl 5-bromo-2-(2-(3-(trifluoromethyl)phenyl)acetamido)benzoate

Product 1

HCID 86716059Methyl 5-bromo-2-(2-(2-chlorophenyl)acetamido)benzoate

Procedure

The title compound was prepared using 2-chlorophenylacetyl chloride in place of 2-phenylacetyl chloride using the procedure described for Intermediate 7: step a.

Sources & evidence

ORD record
ord-b8cd742fa9cc4104bc2c41c451f9ee75
Source dataset
uspto-grants-2016_08
Patent number
US09403816B2

Reaction notes

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