Dimethylformamide → 6-Bromo-1,3,3-trimethyl-2,2-dioxo-pyrido[3,2-c]thiazin-4-one

関与物質

反応条件

反応手順

To a solution of 6-bromo-1-methyl-2,2-dioxo-pyrido[3,2-c]thiazin-4-one (456 mg, 1.56 mmol) in DMF (3 ml) was added K2CO3 (2.16 g, 15.6 mmol) followed by Mel (0.29 ml, 4.7 mmol) at ambient temperature. The suspension was heated to 60° C. for 1.5 h then cooled to ambient temperature, filtered, washed with ethyl acetate and concentrated under reduced pressure. Purification by flash chromatography eluting with ethyl acetate/heptane, gradient, afforded 6-bromo-1,3,3-trimethyl-2,2-dioxo-pyrido[3,2-c]thiazin-4-one.

情報源と証拠