(s)-Tert-butyl 2-(azidomethyl)morpholine-4-carboxylate → (R)-2-Aminomethyl-4-Boc-morpholine

Participants

Reaction Steps

(S)-tert-butyl 2-(azidomethyl)morpholine-4-carboxylate (31 g, 127.95 mmol) was dissolved in MeOH (400 ml), and Pd/C (5%, 6 g) was added, followed by stirring under H2 (gas) for 1 hour. After the completion of the reaction, the reaction mixture was filtered through celite, followed by drying, and then the next reaction was advanced.

Provenance & Evidence