HCID 73504292, compound → HCID 118364796, compound

Participants

Reaction Steps

(S)-2-(4-(2-(2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholino)pyrimidin-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethanol 54 mg (0.11 mmol) was dissolved in methanol 3 ml and methylene chloride 2 ml, and an excess of platinum oxide was added. The mixture was degassed, and a hydrogen balloon was connected, followed by reaction at room temperature for 1 day. After the reaction, the platinum oxide was removed using a celite filter, and separation by PLC (methylene chloride:methanol=5:1) gave a yellow solid 7.7 mg (14%).

Provenance & Evidence