Potassium Carbonate → HCID 118364750, compound

Participants

Reaction Conditions

Reaction Steps

1-((1-(5-bromopyrimidin-2-yl)piperidin-3-yl)methyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (30 mg, 0.066 mmol), 1-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-pyrazole (32 mg, 0.099 mmol), Pd(dppf)2Cl2(2.7 mg, 0.003 mmol), and K2CO3(28 mg, 0.20 mmol) were dissolved in dioxane (1.2 ml)+H2O (0.3 ml), and the mixture was degassed with N2(gas), followed by stirring at 80° C. for 2 hours. After the completion of the reaction, the reaction mixture was extracted with H2O, EA, and brine, followed by drying (Na2SO4), filtration, and concentration under reduced pressure, and the residue was purified by column chromatography (MeOH:MC=1:20), to give 6-(1-methyl-1H-pyrazol-4-yl)-1-((1-(5-(1-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)-1H-pyrazol-3-yl)pyrimidin-2-yl)piperidin-3-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (28 mg, 78%).

Provenance & Evidence