1,4-Dioxane hydrochloride → HCID 118364843, compound

HRID 1478599Notes

Reaction equation

HRID 1478599 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][CH:17]4[CH2:22][CH2:21][CH2:20][N:19]([C:23]5[N:28]=[CH:27][C:26]([C:29]6[CH:33]=[CH:32][N:31]([CH2:34][CH2:35][O:36]C7CCCCO7)[N:30]=6)=[CH:25][N:24]=5)[CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1.O1CCOCC1.[ClH:49]>C(Cl)Cl>[ClH:49].[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][CH:17]4[CH2:22][CH2:21][CH2:20][N:19]([C:23]5[N:24]=[CH:25][C:26]([C:29]6[CH:33]=[CH:32][N:31]([CH2:34][CH2:35][OH:36])[N:30]=6)=[CH:27][N:28]=5)[CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 118364750HCID 118364750, compound

Product 1

HCID 118364843HCID 118364843, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-(1-methyl-1H-pyrazol-4-yl)-1-((1-(5-(1-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)-1H-pyrazol-3-yl)pyrimidin-2-yl)piperidin-3-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (28 mg, 0.049 mmol) was dissolved in CH2Cl2 (5 ml), and then 4 N HCl dioxane (1 ml) was added, followed by stirring at room temperature for 1 hour. After the reaction was completed, the reaction mixture was purified with ether to give 2-(3-(2-(3-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazol-1-yl)ethanolhydrochloride (21.5 mg, 83%).

Workup

  1. customthe reaction mixture was purified with ether

Sources & evidence

ORD record
ord-0e35379a2d9747febc926e6cb7a7648b
Source dataset
uspto-grants-2016_08
Patent number
US09403831B2

Reaction notes

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