Hydrochloric Acid → HCID 118364766, compound

Participants

Reaction Steps

(S)-(4-(2-(3-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)piperidin-1-yl)pyrimidin-5-yl)phenyl)(4-methylpiperazin-1-yl)methanone (48 mg, 0.083 mmol) was dissolved in CH2Cl2 (5 ml), and 4 N HCl in dioxane (1 ml) was added, followed by stirring at room temperature for 1 hour. After the reaction was completed, the reaction mixture was purified with ether to give (S)-(4-(2-(3-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)piperidin-1-yl)pyrimidin-5-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride (46 mg, 90%).

Provenance & Evidence