反应详情

温度

20 °C

A solution of ethyl 5-methylimidazo[1,2-a]pyridine-2-carboxylate (5.0 g, 25 mmol) in acetonitrile (94 mL) was treated with N-bromosuccinimide (4.8 g, 27 mmol) in acetonitrile (47 mL) dropwise and stirred at 20° C. for 30 min. The reaction mixture was concentrated, diluted with dichloromethane (200 mL), and washed with saturated sodium bicarbonate (150 mL) and brine (50 mL). The organic layer was dried with sodium sulfate, filtered, and concentrated to a crude solid. Purification by flash column chromatography gave the desired product (4.0 g, 58%). LCMS for C11H12BrN2O2 (M+H)+: m/z=282.9, 284.9.

1. concentrationThe reaction mixture was concentrated
2. additiondiluted with dichloromethane (200 mL)
3. washwashed with saturated sodium bicarbonate (150 mL) and brine (50 mL)
4. dry with materialThe organic layer was dried with sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated to a crude solid
7. customPurification by flash column chromatography