反应详情

温度

95 °C

A solution of 3-bromo-N-methoxy-N,5-dimethylimidazo[1,2-a]pyridine-2-carboxamide (0.48 g, 1.6 mmol), (3,5-difluorophenyl)boronic acid (0.33 g, 2.1 mmol), and sodium carbonate (0.26 g, 2.4 mmol) in 1,4-dioxane (10 mL) and water (1.9 mL) was degassed with nitrogen and treated with tetrakis(triphenylphosphine)palladium(0) (0.13 g, 0.11 mmol). The reaction mixture was degassed with nitrogen and heated at 95° C. for 19 h. The reaction mixture was concentrated, diluted with ethyl acetate (100 mL), washed with water and brine, dried with sodium sulfate, filtered, and concentrated to a crude solid. Purification by flash column chromatography gave the desired product (0.43 g, 80%). LCMS for C17H16F2N3O2 (M+H)+: m/z=332.1.

1. customThe reaction mixture was degassed with nitrogen
2. concentrationThe reaction mixture was concentrated
3. additiondiluted with ethyl acetate (100 mL)
4. washwashed with water and brine
5. dry with materialdried with sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated to a crude solid
8. customPurification by flash column chromatography