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HRID1478733

反应详情

EQUATION

反应方程式

HRID 1478733 的结构方程式

REACTANTS

反应物

2
反应SMILES：COC[C@@H]1ON=C2CO[C@@H](C3CC3)C[C@H]21
HCID90253552

未命名化合物

反应SMILES：Fc1ccc([C@]23CO[C@@H](C4CC4)C[C@H]2CON3)c(F)c1
HCID118621161

未命名化合物

PRODUCTS

产物

1
反应SMILES：COC[C@@H]1ON[C@@]2(c3ccc(F)cc3F)CO[C@@H](C3CC3)C[C@@H]12
HCID90253561

未命名化合物

PROCEDURE

实验过程

rel-(3R,3aR,5R)-5-Cyclopropyl-3-(methoxymethyl)-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole (C38) was converted to the product using the method described for synthesis of rel-(3aR,5R,7aS)-5-cyclopropyl-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole (C19) in Example 2. The product was obtained as an oil. Yield: 0.85 g, 2.6 mmol, 55%. LCMS m/z 326.2 [M+H+].

WORKUP

后处理

  1. customThe product was obtained as an oil