N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide → HCID 90253573, compound

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Reaction Steps

rel-N-{[(3S,4R,6R)-3-(2,4-Difluorophenyl)-4-(hydroxymethyl)-6-(1-methylcyclopropyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide (C59) was converted to the product using the method described for synthesis of N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide (C8) in Preparation P1. The product was obtained as a white solid. Yield: 1.1 g, 16.8 mmol. LCMS m/z 443 [M+H+].

Provenance & Evidence