HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-N-methoxy-N-methyloxolane-2-carboxamide → 1-[(2S)-tetrahydrofuran-2-yl]but-3-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-N-methoxy-N-methyloxolane-2-carboxamide | HCID 6712977 | — |
| Reactant | 1-[(1R,2R)-2-methylcyclopropyl]but-3-en-1-one | HCID 90253496 | — |
| Product | 1-[(2S)-tetrahydrofuran-2-yl]but-3-en-1-one | HCID 90238443 | — |
Reaction Steps
(2S)—N-Methoxy-N-methyltetrahydrofuran-2-carboxamide (C92) was converted to the product using the method described for the synthesis of 1-[(1R,2R)-2-methylcyclopropyl]but-3-en-1-one (C80) in Example 20. The resulting product was used in the next step without further purification. Yield: 19 g, ≦0.14 mol, ≦87%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403846B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-07bac94c87574982b8c0db993f8dc7dd |
| Source note | uspto-grants-2016_08 |