HCID 90238531, compound → HCID 118621156, compound

HRID 1478774Notes

Reaction equation

HRID 1478774 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[C@H:6]([O:10][CH2:11][CH:12]=O)[CH2:7][CH:8]=[CH2:9].[OH:14][N:15]=CCOC([C@@H]1C[C@H]1C)CC=C>>[OH:14][N:15]=[CH:12][CH2:11][O:10][C@@H:6]([C@@H:2]1[CH2:3][CH2:4][CH2:5][O:1]1)[CH2:7][CH:8]=[CH2:9]

Participants

3

Reactant 2

HCID 90238531HCID 90238531, compoundHCID 118621180HCID 118621180, compound

Product 1

HCID 118621156HCID 118621156, compound

Procedure

({(1R)-1-[(2S)-Tetrahydrofuran-2-yl]but-3-en-1-yl}oxy)acetaldehyde (C97) was converted to the product using the method described for the synthesis of N-hydroxy-2-({1-[(1R,2R)-2-methylcyclopropyl]but-3-en-1-yl}oxy)ethanimine (C84) in Example 20. Yield: 4.7 g, 23.6 mmol, 65% over 2 steps from (C95).

Sources & evidence

ORD record
ord-e081ac15275d491998d31c3b3062a25f
Source dataset
uspto-grants-2016_08
Patent number
US09403846B2

Reaction notes

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