N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide → HCID 90253541, compound

Participants

Reaction Steps

N-({(3S,4R,6R)-3-(2,4-Difluorophenyl)-4-(hydroxymethyl)-6-[(2S)-tetrahydrofuran-2-yl]tetrahydro-2H-pyran-3-yl}carbamothioyl)benzamide (C102) was converted to the product using the method described for the synthesis of N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide (C8) in Preparation P1. Yield: 1.0 g, 2.2 mmol, 87%. LCMS m/z 458.9 [M+H+].

Provenance & Evidence