4-amino-2-cyclohexyl-1,5-dimethyl-2,3-dihydro-1H-pyrazol-3-one → 1-(4-Chloro-2-cyclopropylphenyl)-N-(2-cyclohexyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

HRID 1478807Notes

Reaction equation

HRID 1478807 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=O)[N:10]=[N:9]2)=[C:4]([CH:17]2[CH2:19][CH2:18]2)[CH:3]=1.[NH2:20][C:21]1[C:22](=[O:34])[N:23]([CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[N:24]([CH3:27])[C:25]=1[CH3:26]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:20][C:21]3[C:22](=[O:34])[N:23]([CH:28]4[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]4)[N:24]([CH3:27])[C:25]=3[CH3:26])=[O:16])[N:10]=[N:9]2)=[C:4]([CH:17]2[CH2:19][CH2:18]2)[CH:3]=1

Participants

3

Reactant 2

HCID 612730214-amino-2-cyclohexyl-1,5-dimethyl-2,3-dihydro-1H-pyrazol-3-one2×HCID 1185132721-(4-Chloro-2-cyclopropylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

Product 1

HCID 1185133001-(4-Chloro-2-cyclopropylphenyl)-N-(2-cyclohexyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

Procedure

The title compound was prepared from 1-(4-chloro-2-cyclopropylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (Example 13, step 5) and 4-amino-2-cyclohexyl-1,5-dimethyl-1H-pyrazol-3(2H)-one (Intermediate A) analogously to Example 1, step 3.

Sources & evidence

ORD record
ord-cb7586341a2f45a193c453bd7289bbcb
Source dataset
uspto-grants-2016_08
Patent number
US09403833B2

Reaction notes

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