Methyl iodide → HCID 178497208, compound

HRID 1478835Notes

Reaction equation

HRID 1478835 reaction equation
[S:1]=[C:2]1[NH:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][CH:8]=2)[NH:3]1.[CH3:16]I>CCO>[CH3:16][S:1][C:2]1[NH:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86725245HCID 86725245, compound

Product 1

HCID 178497208HCID 178497208, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of methyl 2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate (110 mg, 0.5 mmol) in anhydrous EtOH (5 mL) was added MeI (0.125 mL, 2 mmol). The reaction mixture was stirred at reflux for 1 hr. After cooling, the solid was isolated by filtration to afford methyl 2-(methylthio)-3,4-dihydroquinazoline-7-carboxylate (100 mg).

Workup

  1. temperatureat reflux for 1 hr
  2. temperatureAfter cooling
  3. customthe solid was isolated by filtration

Sources & evidence

ORD record
ord-7fceffaaa3db417784bb5e7c95c25670
Source dataset
uspto-grants-2016_08
Patent number
US09403850B2

Reaction notes

Loading…