Boron Trichloride → HCID 86725277, compound

HRID 1478880Notes

Reaction equation

[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[C@H:12]([B:29]1[O:37]C2C(C)(C3CC(C2)C3(C)C)[O:30]1)[CH2:13][C:14]1[C:15](OC)=[C:16]([CH:24]=[CH:25][CH:26]=1)[C:17]([O:19]C(C)(C)C)=[O:18].B(Cl)(Cl)Cl>>[O:11]=[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2](=[O:1])[N:3]1[C@H:12]1[CH2:13][C:14]2[CH:26]=[CH:25][CH:24]=[C:16]([C:17]([OH:19])=[O:18])[C:15]=2[O:37][B:29]1[OH:30]

Participants

Reactant 2

HCID 25135Boron Trichloride

HCID 86725279HCID 86725279, compound

Product 1

HCID 86725277HCID 86725277, compound

Procedure

Prepared from tert-butyl 3-((2R)-2-(1,3-dioxoisoindolin-2-yl)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)ethyl)-2-methoxybenzoate and BCl3 following the procedure described in Step 2 of Example 3. ESI-MS m/z 338 (MH)+.

Sources & evidence

ORD record: ord-f50204d9ae5b4fca97224893db7bf981
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09403850B2

Reaction notes

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