Sodium Hydroxide → HCID 89650782, compound

Participants

Reaction Steps

A 5N aqueous solution of NaOH (1.96 mL, 9.82 mmol) was added into a solution of 4-fluoro-2-(1,1,2,2-tetrafluoro-ethoxy)-benzoic acid methyl ester (884 mg, 3.27 mmol) in MeOH (10 mL). The resulting mixture was stirred at RT for 15 hours, then concentrated under vacuum. The residue was taken up with water (20 mL) and acidified until pH=1 with a 1N aqueous solution of HCl. The precipitate was filtered off, washed with water (3×) and dried under vacuum to give the title compound as a white powder (661 mg, 79%). 1H NMR (300 MHz, DMSO-d6) δ 13.38 (s, 1H), 8.02-7.93 (m, 1H), 7.43-7.32 (m, 2H), 6.73 (tt, J=51.7, 3.5 Hz, 1H). HPLC (max plot) 96.8%; Rt 3.72 min. UPLC/MS: (MS−) 255.2 ([M−H]−).

Provenance & Evidence