Hydrochloric Acid → 6-fluoro-5,7-dimethyl-2,3-dihydro-1H-2,4,7a,8-tetraaza-cyclopenta[a]indene hydrochloride

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Reaction Steps

To a solution of 6-fluoro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester (3.39 g; 11.1 mmol; 1 eq.) in DCM (20 mL) was added 2M HCl (10 mL; 20 mmol; 1.81 eq.) and the resulting mixture was stirred at room temperature for 18 hours than concentrated in vacuo. The residue was triturated in DCM and the precipitate was filtered off to afford the title compound (2 g, 80%) as a white solid. HPLC (max plot) 99.6%; Rt 1.23 min. UPLC/MS: (MS+) 207.1 ([M+H]+).

Provenance & Evidence