Hydrochloric Acid → HCID 89650340, compound

Participants

Reaction Steps

NaOH (87 mg; 2.17 mmol; 10 eq.) was added to a solution of 5-fluoro-2-(2-pyridazin-3-yl-ethoxy)-benzoic acid methyl ester (60 mg; 0.22 mmol; 1 eq.) on THF (1 mL) and the reaction mixture was stirred at room temperature for 16 hours. The solution was diluted with water acidified with 0.1M HCl and extracted with DCM (3×). The combined organics were dried over magnesium sulfate and concentrated in vacuo to give the title compound (57 mg, quantitative) as a yellow solid which was used without further purification. UPLC/MS: (MS+) 263.2 ([M+H]+).

Provenance & Evidence