Hydrochloric Acid → HCID 89652879, compound

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Reaction Steps

A solution of (R)-2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carbonyl)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (90 mg; 0.17 mmol; 1 eq.) and 2M HCl (3 mL; 6 mmol; 35 eq.) in DCM (5 mL) was stirred at room temperature for 18 hours then concentrated to dryness. 1M NaOH was added and extracted several times with DCM. The combined organics were dried over magnesium sulfate and concentrated in vacuo. Crystallization from MTBE afforded the title compound (30 mg, 41%) as a yellow solid. 1H NMR (DMSO) δ 7.46-7.39 (m, 1H), 7.31-7.27 (m, 1H), 7.13 (d, J=8.4 Hz, 1H), 7.05-7.00 (m, 1H), 4.82-4.54 (m, 2H), 3.91-3.89 (m, 2H), 3.35-3.25 (m, 1H), 2.84 (s, 1.5H), 2.80 (s, 1.5H), 2.61-2.58 (m, 5H), 1.73-1.30 (m, 4H). HPLC (max plot) 97.1%, Rt 2.65 min. UPLC/MS: (MS+) 426.2 ([M+H]+).

Provenance & Evidence