Ammonium hydroxide methanol → HCID 89662742, compound

Participants

Reaction Steps

To [2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carbonyl)-phenoxy]-difluoro-acetic acid ethyl ester (from example 102 step 1) (70 mg; 0.15 mmol; 1 eq.) was added NH4OH/MeOH and the reaction mixture was stirred at room temperature for 1.5 hour then concentrated in vacuo. The residue taken up in EA, washed sat. aq. NH4Cl, dried over magnesium sulfate and concentrated in vacuo. Purification by mass directed preparative HPLC afforded the title compound (25 mg, 38%) as a white solid. HPLC (max plot) 99.6%, Rt 3.28 min. UPLC/MS: (MS+) 436.4 ([M+H]+).

Provenance & Evidence