Hydrochloric Acid → HCID 122512305, compound

Participants

Reaction Steps

A 4M solution of HCl in 1,4-dioxane (2.51 mL; 10.04 mmol; 5 eq.) was added to a solution of 3-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carbonyl)-phenoxy]-azetidine-1-carboxylic acid tert-butyl ester (1 g; 2.01 mmol; 1 eq.) in 1,4-dioxane (15 mL) and the resulting mixture was stirred at room temperature for 3.5 hours. A 4M solution of HCl in 1,4-dioxane (1 mL; 4 mmol; 2 eq.) was added and the reaction mixture was stirred at room temperature for 2.5 hours then concentrated in vacuo. The residue was taken up in water and the pH made basic. The solution was extracted with DCM and the organic layer dried over magnesium sulfate and concentrated in vacuo. Purification by mass directed preparative HPLC afforded the title compound (60 mg, 7%) as a white solid. 1H NMR (CDCl3) δ 8.41 (s, 1H), 7.40-7.33 (m, 4H), 7.14-7.07 (m, 1H), 6.66-6.62 (m, 1H), 5.13-5.07 (m, 1H), 4.97 (s, 2H), 4.59 (s, 2H), 4.29-4.23 (m, 2H), 3.97-3.92 (m, 2H), 2.88 (s, 2H), 2.83 (s, 1H), 2.67 (s, 1H), 2.60 (s, 2H). HPLC (max plot) 97.3%, Rt 2.45 min. UPLC/MS: (MS+) 398.4 ([M+H]+).

Provenance & Evidence