Tetrahydrofuran → HCID 89662807, compound

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Reaction Steps

A mixture of [2-(2-{[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-methyl-amino}-ethoxy)-phenyl]-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]inden-2-yl)-methanone (40 mg; 0.07 mmol; 1 eq.) and a 1M solution of tetrabutyl-ammonium fluoride in THF (0.09 mL; 0.09 mmol; 1.2 eq.) was stirred at room temperature for 3 hours. The solution was diluted with EA, washed with water, dried over magnesium sulfate and concentrated in vacuo. Purification by column chromatography (EA to 20% MeOH in EA) afforded the title compound (12 mg, 38%) as a colourless oil. HPLC (max plot) 95.8%, Rt 2.56 min. UPLC/MS: (MS+) 444.3 ([M+H]+).

Provenance & Evidence