Hydrochloric Acid → HCID 89662771, compound

Participants

Reaction Steps

A 4M solution of HCl in 1,4-dioxane (0.47 mL; 1.87 mmol; 10 eq.) was added to a solution of trans-4-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-2-trifluoromethyl-piperidine-1-carboxylic acid tert-butyl ester (115 mg; 0.19 mmol; 1 eq.) in 1,4-dioxane (5 mL) and the reaction mixture was stirred at room temperature for 16 hours. 5M NaOH was added and the mixture extracted with DCM (3×). The combined organics were washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was dissolved in ACN/water and freeze-dried to afford the title compound (34 mg, 35%) as a yellow solid. 1H NMR (CDCl3) δ 7.45-7.29 (m, 1H), 6.91-6.74 (m, 1H), 6.74-6.60 (m, 1H), 5.12-4.91 (m, 2H), 4.84-4.53 (m, 3H), 3.56-3.29 (m, 1H), 3.07-2.79 (m, 5H), 2.78-2.55 (m, 3H), 2.22-1.99 (m, 1H), 1.99-1.86 (m, 1H), 1.86-1.56 (m, 3H). HPLC (max plot) 92.5%, Rt 3.10 min. UPLC/MS: (MS+) 512.3 ([M+H]+).

Provenance & Evidence