Toluene → HCID 71073554, compound

Participants

Reaction Steps

First, 10 g of ethyl benzimidate hydrochloride, 150 mL of toluene, and 11 g of triethylamine (Et3N) were put into a 500-mL three-neck flask and this mixture was stirred at room temperature for 10 minutes. After a predetermined time elapsed, with a 50-mL dropping funnel, a mixed solution of 5.8 g of butyryl chloride and 30 mL of toluene was added dropwise to this mixture, and the mixture was stirred at room temperature for 24 hours. After the stirring, this mixture was suction-filtered, and the obtained filtrate was concentrated to give N-(1-ethoxybenzylidene)butyramide (a yellow oily substance, 100% yield). The synthesis scheme of Step 1 is shown in (A-1) below.

Provenance & Evidence