Toluene → HCID 86674301, compound

Participants

Reaction Steps

First, 10 g of ethyl benzimidate hydrochloride, 150 mL of toluene, and 11 g of triethylamine (Et3N) were put into a 500-mL three-neck flask and the mixture was stirred at room temperature for 10 minutes. After a predetermined time elapsed, with a 50-mL dropping funnel, a mixed solution of 3.8 g of acetyl chloride and 30 mL of toluene was added dropwise to this mixture, and the mixture was stirred at room temperature for 24 hours. The obtained mixture was suction-filtered, and the obtained filtrate was concentrated to give N-(1-ethoxybenzylidene)acetamide (a yellow oily substance, 100% yield). The synthesis scheme of Step 1 is shown in (B-1) below.

Provenance & Evidence