P-Toluenesulfonylhydrazide → HCID 89760832, compound

HRID 1479155Notes

Reaction equation

HRID 1479155 reaction equation
[C:1]1([CH3:12])[CH:6]=[CH:5][C:4]([S:7]([NH:10][NH2:11])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[F:13][CH:14]([F:24])[O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1>CO>[S:7]([NH:10][N:11]=[CH:4][C:3]1[CH:2]=[CH:1][CH:6]=[CH:5][C:20]=1[C:19]1[CH:22]=[CH:23][C:16]([O:15][CH:14]([F:24])[F:13])=[CH:17][CH:18]=1)([C:4]1[CH:3]=[CH:2][C:1]([CH3:12])=[CH:6][CH:5]=1)(=[O:8])=[O:9]

Participants

4

Reactant 2

HCID 15303P-ToluenesulfonylhydrazideHCID 2736986p-(Difluoromethoxy)benzaldehyde

Product 1

HCID 89760832HCID 89760832, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Tolylsulfonyl hydrazine (6.03 g, 182 mmol) was added to a stirred solution of 4-difluoromethoxy-benzaldehyde (5 g, 172 mmol) in methanol (6 ml). Everything dissolved. After two hours the solvent was evaporated to yield 9.8 g (99%) of a white solid.

Workup

  1. dissolutionEverything dissolved
  2. customAfter two hours the solvent was evaporated

Sources & evidence

ORD record
ord-14bc7fe7f23d4c2d9f18920005d65bbc
Source dataset
uspto-grants-2016_08
Patent number
US09408392B2

Reaction notes

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