Ethyl Acetate → HCID 89760871, compound

Participants

Reaction Steps

2,6-difluorobenzoyl chloride (156 mg, 0.881 mmol) was added to a rapidly stirred mixture of NaHCO3 (1 M aq., 4 ml) and a solution of racemic (1R,2R)-2-(4-chlorophenyl)-2-methyl-cyclopropanamine hydrochloride (172 mg, 0.735 mmol) in dichloromethane (4.5 ml). After stirring for 30 minutes EtOAc was added, the organic phase was separated, washed with brine, dried over MgSO4, and the solvent evaporated to give 241 mg, 100%) of racemic N-[(1R,2R)-2-(4-chlorophenyl)-2-methyl-cyclopropyl]-2,6-difluoro-benzamide. M.p. 140-142° C.

Provenance & Evidence