Ethyl diazoacetate → HCID 117795939, compound

Participants

Reaction Steps

Ethyl diazoacetate (1.61 g, 12 mmol) was added over 90 minutes to a mixture of rhodium acetate (44 mg) in E-1-(4-chlorophenyl)-1-propene (2.243 g, 12 mmol) at 90° C. with stirring. Heating was continued for 60 minutes. On cooling the mixture was chromatographed with EtoAc/hexane to yield 170 mg of racemic ethyl (1R,2S,3S)-2-(4-chlorophenyl)-3-methyl-cyclopropanecarboxylate. (Another isomer was also isolated.)

Provenance & Evidence