Triethylamine → HCID 89760735, compound

Participants

Reaction Steps

2-Trifluoromethyl-benzoyl chloride (0.028 ml, 39.4 mg, 0.17 mmol) was added to a solution of racemic (1R,2R,3S)-2-(4-chlorophenyl)-3-methyl-cyclopropanamine hydrochloride (37.2 mg, 0.17 mmol), and triethylamine (43.4 mg) in THF at 0° C. with stirring, and stirred for 18 hours. The white solid of Et3NHCl was filtered off and the filtrate concentrated and chromatographed with diethyl ether/hexane to yield 20 mg of pure racemic N-[(1R,2R,3S)-2-(4-chlorophenyl)-3-methyl-cyclopropyl]-2-(trifluoromethyl)benzamide. M.p. 167-9

Provenance & Evidence