HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formate → 3-(4-bromophenyl)-7-hydroxy-4H-chromen-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formate | HCID 283 | — |
| Reactant | Resorcinol | HCID 5054 | — |
| Reactant | Benzeneacetyl chloride, 4-bromo- | HCID 181552 | — |
| Reactant | 2-(4-bromophenyl)-1-(2,4-dihydroxyphenyl)ethanone | HCID 2063466 | — |
| Product | 3-(4-bromophenyl)-7-hydroxy-4H-chromen-4-one | HCID 5398367 | — |
Reaction Steps
Resorcinol is reacted with 2-(4-bromophenyl)acetyl chloride forming the product 2-(4-bromophenyl)-1-(2,4-dihydroxyphenyl)ethanone. Such reactions are described in Chemistry of Heterocyclic Compounds (NY, N.Y., USA) 1977 Vol., 13, p. 948-953. The product is reacted with triethylorth formate to form 3-(4-bromophenyl)-7-hydroxy-chromen-4-one which can be reacted with methane sulfonyl chloride and a base to form [3-(4-bromophenyl)-4-oxo-chromen-7-yl] methanesulfonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09408826B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-eb298c12ad334cf1935502297d6280af |
| Source note | uspto-grants-2016_08 |