1-(2-Pyrimidinyl)piperazine → 4,6-Diphenyl-3-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-chloro-4,6-diphenylpyridazine (267 mg, 1.0 mmol), 1-(2-pyrimidyl)piperazine (656 mg, 4.0 mmol) 3 ml of 1-BuOH was heated with stirring at 130° C. for 3 days. The solvent was removed by evaporation in vacuo the residue was treated with water to give a suspension. The solid was then filtered off, washed with water, dried over filter funnel in vacuo to give light pink solid. (320 mg, 0.81=01, yield 81.1%). ESI-MS: m/z 395.5 (M+H+), HRMS calcd 395.1979. Found 395.1973; 1H NMR (CDCl3): d 8.329 (d, 2H), 8.101 (d, J=7.5, 2H), 7.734 (d, J=7.5, 2H), 7.655 (s, 1H), 70509 (m, 6H), 6.530 (t, J=4.5, 1H), 3.836 (1, J=4.5, J=5.0, 4H), 3.394 (t, J=5.0, J=4.5, 4H).

Provenance & Evidence