反应详情

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0 °C

(S)-4-(6-((2,3-dihydroxypropoxy)carbonyl)-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinolin-10-yl)-1-methylpiperazin-1-ium 2,2,2-trifluoroacetate (0.50 g, 0.91 mmol) was dissolved in methanol under argon and cooled to 0° C. (ice/salt bath). 1 equiv. of NaOH dissolved in methanol (25 ml) was added slowly until the solution reached pH 7-pH 8. The reaction mixture was passed through a plug of Al2O3 (10% MeOH in CHCl3). The organic solvent was removed under reduced pressure giving a yellow solid (0.35 g, 88%)

1. additionwas added slowly until the solution
2. customThe organic solvent was removed under reduced pressure